Chemical genomics is the bridge and link of genomic and new drug research. It refers to the use of a small molecule compound-identified in a highly specific to target protein-to analyze gene function and discovery new drug leads. With the integration of the related technologies of combinatorial chemistry, genomics, proteomics, molecular biology, pharmacology etc., chemical genomics use bioactive small molecular compound legend as probe to examine the functions of genes and proteins closely related with human diseases，and at the same time to provide high-affinity drug leads.
The so-called chemical genomics drug discovery model is first understand the mechanisms of disease through functional genomics research and find and confirm the drug targets, then find the pharmaceutical composition through chemical synthesis and high throughput screening methods. The results of human genomics project provide a lot of information reveal the mechanisms of human disease. The genes or proteins related with human disease indicated by human genomics project could both be the potential drug targets.
As a new method，chemical genomics drug discovery model accelerate the pace of drug discovery. In addition, chemical genomics has a unique advantage in small-molecule drug research and promotes the development process of small molecule drugs. The improvement of the efficiency of drug discovery，which always concerned as the first step of drug research，make the development of medical level and pharmaceutical industry to a new level.