Recently, a study published in “Nature” successful discovered the inhibitor of insulin degrading enzyme (IDE). Insulin degrading enzyme is a kind of protein which-will destroy the insulin in the body-is responsible for diabetes susceptibility. The found of this inhibitor might lead to new treatments for diabetes.
The patients with type II diabetes could not produce sufficient amounts of insulin, and insulin degrading enzyme could remove insulin from the blood. So far, the treatment strategy in patients with diabetes is insulin injections or taking drugs to make the body more sensitive to insulin, or taking other drugs to stimulate insulin secretion.
In this study, the authors revealed a potential new treatment that regulates insulin degradation in the blood. They demonstrate the feasibility of modulating insulin degrading enzyme activity as a new therapeutic strategy to treat type II diabetes. The research also expands our understanding of the roles of insulin degrading enzyme in glucose and hormone regulation.
“The research results gives proof of concept that targeting this protein is extremely promising. The inhibitor we discovered successfully relieved the symptoms of type II diabetes in obese mice and not only elevated their insulin levels but promoted healthy insulin signaling within the blood.” said Dr. Seeliger, Assistant Professor in the Department of Pharmacological Sciences at Stony Brook University School of Medicine.